{"id":8247,"date":"2022-01-19T05:50:48","date_gmt":"2022-01-19T05:50:48","guid":{"rendered":"https:\/\/www.marrow.com\/blog\/?p=8247"},"modified":"2022-01-19T08:13:58","modified_gmt":"2022-01-19T08:13:58","slug":"top-10-marrow-updates-for-neet-pg-2022","status":"publish","type":"post","link":"https:\/\/www.marrow.com\/blog\/top-10-marrow-updates-for-neet-pg-2022\/","title":{"rendered":"Top 10 Marrow Updates for NEET PG 2022"},"content":{"rendered":"\n<p style=\"background-color:#dfe9f2\" class=\"has-background wp-block-paragraph\"><em>The NEET PG 2022 is almost here. It&#8217;s time to look back on the Top 10 Marrow updates of 2021. These are some of the most important, exam-relevant updates for the upcoming NEET PG exam. To see the complete list of recent updates from 2021 and 2022,&nbsp;<\/em><a href=\"marrow:\/\/recent_updates\">click here<\/a> <em>or check out the Recent Updates section on your Marrow app.<\/em><\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong><span style=\"color:#21546a\" class=\"has-inline-color\">1<\/span> <span style=\"color:#21546a\" class=\"has-inline-color\">Translocases: The 7th enzyme class<\/span><\/strong><\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Earlier, there were only six enzyme classes.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The enzymes that catalyze the movement of ions across membranes or their separation within membranes have now been classified under a new enzyme class of <strong>Translocases<\/strong> (EC 7).<\/p>\n\n\n\n<p class=\"has-background has-very-light-gray-background-color wp-block-paragraph\"><span style=\"color:#671616\" class=\"has-inline-color\"><strong>Updated MCQs: MB0798, MB0799<\/strong>.  <strong>Pearl: 2426<\/strong><\/span>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><span style=\"color:#21546a\" class=\"has-inline-color\"><strong>2. National Leprosy Eradication Program 2020: Indicators<\/strong><\/span><\/h4>\n\n\n\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\">\n<p class=\"wp-block-paragraph\"><strong>Essential indicators<\/strong><strong>:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Annual case detection rate\/lakh population.<\/li><li>Rate of new cases with Grade II disabilities\/10lakh population\/year<\/li><li>Treatment completion rate as a proxy to cure rate.<\/li><li>Prevalence rate.<\/li><\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">&nbsp;<strong>Epidemiological Indicators<\/strong>:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>The proportion of Grade II disabilities among new cases.<\/li><li>The proportion of females among new cases.&nbsp;<\/li><li>The proportion of MB among new cases.<\/li><li>The proportion of child (0- 14 years) among new cases.&nbsp;<\/li><li>Child rate per 100,000 population.&nbsp;<\/li><li>Scheduled caste New Case Detection Rate.<\/li><\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">&nbsp;<strong>Quality of service indicators<\/strong><strong>:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Patient month Blister calendar pack stock.&nbsp;<\/li><li>An absolute number of patients made RFT.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<\/li><li>A number of relapses were reported.&nbsp;<\/li><li>The proportion of cases who developed new or additional disability after starting MDT.&nbsp;<\/li><li>The proportion of treatment defaulters.<\/li><li>The proportion of new cases correctly diagnosed.<\/li><\/ul>\n<\/div><\/div>\n<\/div><\/div>\n\n\n\n<p class=\"has-background has-very-light-gray-background-color wp-block-paragraph\"><strong><span style=\"color:#671616\" class=\"has-inline-color\">MCQ ID: MD7238, MD7239<\/span><\/strong><\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><span style=\"color:#21546a\" class=\"has-inline-color\"><strong>3. Guideline for Tuberculosis Preventive Treatment <\/strong><\/span><\/h4>\n\n\n\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\">\n<p class=\"wp-block-paragraph\">According to the latest guidelines by NTEP, TB preventive treatment (TPT) is given to the following groups of people.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>i.<\/strong> Rule out active TB and provide TPT, in,<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>People living with HIV<\/li><li>Household contacts of drug-sensitive pulmonary TB patients &lt; 5 years<\/li><\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>ii.<\/strong> Rule out active TB and provide TPT only if TB infection test is positive but chest X-ray is normal, in,<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Household contacts of drug-sensitive pulmonary TB patients \u2265 5 years.<\/li><\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Other risk groups:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Children\/adults on immunosuppressive therapy<\/li><li>Silicosis<\/li><li>Anti-TNF treatment<\/li><li>Patients on Dialysis\/ who underwent Transplantation<\/li><\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>iii<\/strong>. To provide TPT after completion of TB treatment, In children\/adults living with HIV who successfully completed TB treatment<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Treatment options:<\/strong> <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Any of the two available regimens can be provided:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>6 months daily Isoniazid<\/li><li>3 months weekly Isoniazid + Rifapentine (only used when age &gt; 2 years)<\/li><\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Contraindications:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Active TB\/ hepatitis<\/li><li>Peripheral neuropathy<\/li><li>Regular alcohol consumption<\/li><\/ul>\n<\/div><\/div>\n\n\n\n<p class=\"has-background has-very-light-gray-background-color wp-block-paragraph\"><strong><span style=\"color:#671616\" class=\"has-inline-color\">MCQ ID: MC4992<\/span><\/strong><\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong><span style=\"color:#21546a\" class=\"has-inline-color\">4. SUMAN (Surakshit Matritva Aashwasan)<\/span><\/strong><\/h4>\n\n\n\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\">\n<p class=\"wp-block-paragraph\">It is an initiative for \u201czero preventable maternal and newborn death\u201d.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Objectives:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Provide assured, dignified, respectful, &amp; quality healthcare at no cost.<\/li><li>Zero tolerance for denial of services for every woman and newborn visiting the public health facility.<\/li><li>To end all preventable maternal and newborn deaths to provide a positive birthing experience.<\/li><\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Beneficiaries:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>All pregnant women.<\/li><li>All mothers up to 6 months post-delivery.<\/li><li>All sick infants.<\/li><\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Initiatives: <\/strong>(provided free of cost)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Ambulance services.<\/li><li>Minimum 4 antenatal check-ups.<\/li><li>Normal delivery or C-section delivery.<\/li><li>Medicines, lab tests for mother &amp; baby up to 1 year.<\/li><li>Grievance redressal mechanism.<\/li><\/ul>\n<\/div><\/div>\n<\/div><\/div>\n\n\n\n<p class=\"has-background has-very-light-gray-background-color wp-block-paragraph\"><span style=\"color:#671616\" class=\"has-inline-color\"><strong>MCQ ID<\/strong>: <strong>MC4735<\/strong><\/span><\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong><span style=\"color:#21546a\" class=\"has-inline-color\">5. The Medical Termination of Pregnancy Bill, 2020<\/span><\/strong><\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">The Rajya Sabha has passed the MTP (Amendment) Bill, 2020 that increases the time period within which an abortion may be carried out.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Allows abortion to be done on the advice of <strong>one doctor<\/strong> up to <strong>20 weeks<\/strong>, and <strong>two doctors<\/strong> in the case of certain categories of women (survivors of rape, victims of incest, differently-abled women, minors etc.) between <strong>20 and 24 weeks<\/strong>.<\/li><li>The Bill sets up <strong>state-level medical boards<\/strong> to decide if pregnancy may be terminated <strong>after 24 weeks<\/strong> in cases of substantial foetal abnormalities.&nbsp;&nbsp;<\/li><\/ul>\n\n\n\n<p class=\"has-background has-very-light-gray-background-color wp-block-paragraph\"><strong><span style=\"color:#671616\" class=\"has-inline-color\">MCQ ID: MA1063, MD2354.  Pearl ID: 2131<\/span><\/strong><\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong><span style=\"color:#21546a\" class=\"has-inline-color\">6. Pathology- Robbins 10th edition<\/span><\/strong><\/h4>\n\n\n\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\">\n<p class=\"wp-block-paragraph\">i. <strong>Familial breast cancer<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Single gene mutations associated with familial breast cancer can be categorized into:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>High penetrance germline mutations &#8211; BRCA1, BRCA2, TP53, PTEN, STK11, CDH I, PALPB2.<\/li><\/ul>\n\n\n\n<ul class=\"wp-block-list\"><li>Moderate penetrance germline mutations &#8211; ATM, CHEK2.<\/li><\/ul>\n<\/div><\/div>\n\n\n\n<p class=\"has-background has-very-light-gray-background-color wp-block-paragraph\"><strong><span style=\"color:#671616\" class=\"has-inline-color\">MCQ ID: MA5688<\/span><\/strong><\/p>\n\n\n\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\">\n<p class=\"wp-block-paragraph\">ii. <strong>Endometrial carcinoma<\/strong>:&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Recently, genomic sequencing of endometrial carcinoma has revealed four major molecular subtypes of endometrioid and serous carcinomas.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">They are:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Ultramutated\/POLE tumours &#8211; mutations in DNA polymerase \u03b5.<\/li><li>Hypermutated\/MSI (microsatellite instability) tumours &#8211; mutations in\/ epigenetic silencing of mismatch repair genes.<\/li><li>Copy number low\/MSS (microsatellite stable) tumours &#8211; mutations that upregulate signalling through the PI3K\/AKT pathway.<\/li><li>Copy number high\/serous-like tumors &#8211; TP53 mutations &amp; numerous genomic copy number variants.<\/li><\/ul>\n<\/div><\/div>\n\n\n\n<p class=\"has-background has-very-light-gray-background-color wp-block-paragraph\"><strong><span style=\"color:#671616\" class=\"has-inline-color\">MCQ ID: MA6197<\/span><\/strong><\/p>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\">\n<p class=\"wp-block-paragraph\">iii. <strong>Pathogenesis of Kaposi sarcoma<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">As per the latest edition, the pathogenesis of Kaposi sarcoma that is caused by HHV8 includes:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>A virally encoded G protein that induces VEGF production, stimulating endothelial growth.<\/li><li>The lytic infection caused by HHV8 increases pro-inflammatory cytokines.<\/li><li>HHV8 encoded proteins inhibit the p53 induced apoptosis.<\/li><\/ul>\n<\/div><\/div>\n\n\n\n<p class=\"has-background has-very-light-gray-background-color wp-block-paragraph\"><strong><span style=\"color:#671616\" class=\"has-inline-color\">MCQ ID: MB8254<\/span><\/strong><\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><span style=\"color:#21546a\" class=\"has-inline-color\"><strong>7. Inflammatory markers in COVID-19<\/strong><\/span><\/h4>\n\n\n\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\">\n<p class=\"wp-block-paragraph\">Current evidence shows that higher levels of peripheral blood inflammatory markers reflect the intensity of inflammation and the associated with the severity of COVID-19.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">They are,<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Neutrophil: Lymphocyte ratio<\/li><li>High-sensitivity C-reactive protein<\/li><li>IL-6 &amp; IL-10&nbsp;<\/li><li>Lower Lymphocyte: Monocyte ratio<\/li><\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">A positive correlation has been found between an increase in <strong>IL-6 levels<\/strong> and the <strong>risk of mortality<\/strong>.&nbsp;<\/p>\n<\/div><\/div>\n\n\n\n<p class=\"has-background has-very-light-gray-background-color wp-block-paragraph\"><strong><span style=\"color:#671616\" class=\"has-inline-color\">MCQ ID: MD7459<\/span><\/strong><\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong><span style=\"color:#21546a\" class=\"has-inline-color\">8. WHO clinical case definition of post-Covid-19 condition<\/span><\/strong><\/h4>\n\n\n\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\">\n<p class=\"wp-block-paragraph\">WHO published the clinical case definition for post-Covid-19 condition.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">It states \u2018Post Covid-19 condition occurs in individuals with a history of probable or confirmed SARS CoV-2 infection, usually 3 months from the onset of Covid-19, with symptoms that last for at least 2 months and cannot be explained by an alternative diagnosis. Symptoms may be new-onset following initial recovery from an acute Covid-19 episode or persist from the initial episode.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Common symptoms &#8211; fatigue, shortness of breath, &amp; cognitive dysfunction.&nbsp;<\/p>\n<\/div><\/div>\n\n\n\n<p class=\"has-background has-very-light-gray-background-color wp-block-paragraph\"><strong><span style=\"color:#671616\" class=\"has-inline-color\">MCQ ID: MF1980<\/span><\/strong><\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong><span style=\"color:#21546a\" class=\"has-inline-color\">9. New COVID-19 vaccination rules recommended by NEGVAC<\/span><\/strong><\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">NEGVAC guidelines for the administration of the COVID-19 vaccine, accepted by the MoHFW:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Vaccination to be deferred by 3 months after recovery by individuals with lab proven positive COVID-19 illness.<\/li><li>If infected with COVID after the 1st dose of vaccine, 2nd dose is to be deferred by 3 months after clinical recovery.<\/li><li>A gap of 4-8 weeks is recommended before taking the vaccine, for patients with other serious illnesses requiring hospitalization\/ICU care.<\/li><li>Blood donation can be done after 14 days of either receiving the COVID-19 vaccine or testing RT-PCR negative if suffering from COVID-19 disease.<\/li><li>Screening by rapid antigen test prior to vaccination is not required.<\/li><li>Vaccination is recommended for all lactating women.<\/li><\/ul>\n\n\n\n<p class=\"has-background has-very-light-gray-background-color wp-block-paragraph\"><strong><span style=\"color:#671616\" class=\"has-inline-color\">MCQ ID: MD6851<\/span><\/strong><\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><span style=\"color:#21546a\" class=\"has-inline-color\">10. <strong>Multisystem inflammatory syndrome in children &amp; adolescents <\/strong>associated with COVID-19<\/span><\/h4>\n\n\n\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\">\n<p class=\"wp-block-paragraph\">The diagnostic criteria and management guidelines for MIS-C by MoHFW<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Children &amp; adolescents 0\u201318 years of age with fever \u2265 3 days with evidence of COVID-19, or contact with COVID-19 patients &amp; no other obvious microbial cause of inflammation&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">AND two of these:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Rash or bilateral non-purulent conjunctivitis or mucocutaneous inflammation signs&nbsp;<\/li><li>Hypotension or shock<\/li><li>Features of myocardial dysfunction, pericarditis, valvulitis, or coronary abnormalities&nbsp;<\/li><li>Evidence of coagulopathy&nbsp;<\/li><li>Acute gastrointestinal problems&nbsp;<\/li><\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">AND<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Elevated ESR or C-reactive protein, or procalcitonin<\/li><\/ul>\n<\/div><\/div>\n<\/div><\/div>\n\n\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/lh3.googleusercontent.com\/dW-TOr975ySHyzxHlRJtapcqguhGicJpy2_Ajd3Uyh-tGEA-SKz5P8sGbdL9-CQe81x_1Vik9I6G09eeBBx-z-gyLq1_AKLHXDOs650ToYVwigUB5Ul5KoMGd7iRTIqhyxxfYrrA\" alt=\"\"\/><\/figure>\n\n\n\n<p class=\"has-background has-very-light-gray-background-color wp-block-paragraph\"><strong><span style=\"color:#671616\" class=\"has-inline-color\">MCQ ID: MD7149<\/span><\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"marrow:\/\/recent_updates\">Click here<\/a>\/ scroll down to the bottom in the Marrow app to Check out the Recent updates section to view more such Interesting &amp; High-Yield updates. <\/p>\n","protected":false},"excerpt":{"rendered":"<p>The NEET PG 2022 is almost here. It&#8217;s time to look back on the Top 10 Marrow updates of 2021.&#46;&#46;&#46;<\/p>\n","protected":false},"author":27,"featured_media":8258,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_uag_custom_page_level_css":"","_exactmetrics_skip_tracking":false,"_monsterinsights_skip_tracking":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2},"jetpack_post_was_ever_published":false},"categories":[574],"tags":[605],"class_list":["post-8247","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-neet-pg","tag-neet-pg-2022"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Top 10 Marrow Updates for NEET PG 2022 -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marrow.com\/blog\/top-10-marrow-updates-for-neet-pg-2022\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Top 10 Marrow Updates for NEET PG 2022 -\" \/>\n<meta property=\"og:description\" content=\"The NEET PG 2022 is almost here. 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